"The fourth Great Shinobi World War has ended. But Sasuke decides to continue his solitary journey—this time to atone for his sins. Meanwhile, back at the Leaf Village, there is a growing number of missing shinobi. As Kakashi—the sixth Hokage—and the others discuss these incidents, the Leaf is attacked by a mysterious group of shinobi."

Instead of returning to the Hidden Leaf, Sasuke sets out with Chino and Nowaki to investigate the cause of the exploding humans.

Orochimaru brings Sasuke to the Coliseum fighting ring, to lure out En Oyashiro, who may have some information regarding the Exploding Human incident. The match is called off when more Exploding Humans appear and the opportunity to meet Oyashiro seems lost. However, impressed by Sasuke’s Sharingan, Oyashiro approaches him in person.

Sasuke uncovers Fuushin’s true identity at last, and begins to fight him. The moment Sasuke tries to read Fuushin’s memories with his Sharingan, a wave of genjutsu from a massive red eye causes Sasuke to lose consciousness. He awakens to find himself alone, and sees tracks in the snow that indicate Fuushin has barely escaped alive.

Sasuke begins his own investigation into the incidents. He overcomes many dangers on his path to the truth. The Exploding Humans, the Ketsuryugan, the Chinoike Clan, and the Uchiha Clan—just how are they connected? Where does his journey lead? The mystery is about to be solved...