After escaping from Central Prison, the Freezing Alchemist, Isaac McDougal, sets his plan in motion to kill Führer King Bradley. However, under the command of Lt. Col. Roy Mustang, the military and State Alchemists attempt to stop him.

After learning about what happened to Shou Tucker and his daughter Nina, the Elric brothers begin to question what alchemy really is. Meanwhile, Colonel Mustang and the other State Alchemists track down the serial killer Scar.

Mustang, Alphonse, Havoc, and Hawkeye split up to search a military laboratory. If Lust has her way, none of them will ever see each other alive again.

The battle for a nation's soul descends into chaos. Bradley unleashes death on those who dare engage him. Beneath Central, the one responsible for the Fuhrer's creation unleashes something far, far worse.

The light is gone. Shadows swallow everything. As the planet quakes and the heavens tremble, the souls of heroes and villains alike vanish into darkness. The circle is complete.