After escaping from Central Prison, the Freezing Alchemist, Isaac McDougal, sets his plan in motion to kill Führer King Bradley. However, under the command of Lt. Col. Roy Mustang, the military and State Alchemists attempt to stop him.

After investigating the twisted roots of the Bradley family tree, Mustang gathers his most loyal troops. Meanwhile, Ed and his allies continue fighting Selim, who shocks everyone by turning on his own kind.