A neurosurgeon is assassinated just before performing a surgery. The investigation uncovers the truth behind the disappearance of four reform school boys over 40 years ago. Meanwhile, McGarrett's beloved Mercury Marquis is stolen by an unlikely culprit.

McGarrett enlists Joe's help after Danny and Chin are arrested for deadly past transgressions.

While Five-0 investigates a scuba diver’s death from a gun recently used in another murder, McGarrett prepares to propose to Catherine.

Five-0 goes back to school when a college professor is killed and Danny goes undercover as his replacement.

Five-0 goes on a manhunt when a deliberate chemical spill enables six dangerous inmates to escape, including Kono’s husband, Adam.

In order to stop a meth epidemic on the Island, McGarrett and Danny go undercover as pilots, but when McGarrett is seriously wounded, Danny is forced to break their cover in order to save his partner’s life.

McGarrett and Five-0 once again become entangled in the twisted mind games of serial killer Dr. Madison Gray when she stumbles into HPD covered in blood that matches Alicia Brown's, and claims amnesia.

MacGarrett and Danny finally track down the missing uranium, which has been used to build a bomb located in the middle of the jungle. Now, they must carefully extract the unstable explosive through treacherous terrain before it detonates.

McGarrett risks his life when Five-0 attempts their most dangerous rescue yet of young girls trapped in the sex trafficking ring they have been tracking this year. Also, Kono, deeply affected by the case, makes a life-changing decision.

McGarrett and Danny recruit Tani Rey to join the task force when diabolical hacker Aaron Wright releases a dangerous arsonist from prison.

The lives of Five-0’s informants are in danger when the HPD system is hacked and one ends up dead, forcing McGarrett to enlist the help of hacker Aaron Wright (Joey Lawrence), who he just imprisoned

McGarrett and Five-0 discover a Russian spy ring hiding in plain site on Oahu when a Russian nuclear attack submarine appears on the coast of Waikiki. Also, Tani is conflicted by her unnerving discovery at Adam's house.

Thanksgiving brings Grover’s parents and brother Percy Jr. to Oahu for a visit tainted by sibling rivalry, and Five-0 investigates a thief who is crushed to death by an empty safe.