Chin Ho is kidnapped and wakes to find himself trapped in Halawa prison disguised as an inmate. With no time to waste, the team must bypass the rules to save Chon Ho’s life.

A neurosurgeon is assassinated just before performing a surgery. The investigation uncovers the truth behind the disappearance of four reform school boys over 40 years ago. Meanwhile, McGarrett's beloved Mercury Marquis is stolen by an unlikely culprit.