Steve McGarrett is summoned home to the island of Honolulu to bury his father after he is murdered by a madman. Governor Jameson wants Steve to head up a new elite police unit and she will give him full authority to get the job done. Initially he turns down the job, but when he meets the man in charge of the unit, he changes his mind.

When the daughter of the U.S. ambassador to the Philippines is found dead, the governor tasks Five-0 with finding her abducted sister.

McGarrett discovers new clues in his mother's murder when his sister is kidnapped.

When Five-0 gets too close to the truth about Wo Fat and his associates, the criminal mastermind retaliates by trying to destroy the team. They've always played by their own rules, but when the Governor can no longer protect them, it's time for Five-0 to pay the consequences of their actions.