It's the worst kind of overexposure when world-renowned photographer Renny Sinclair is murdered while on assignment in Hawaii shooting the annual swimsuit edition of a top sports magazine.

With the invaluable information that was shared by Agent Jenna Kaye, Five-0 is closer than ever to capturing Wo Fat. Their mission takes an abrupt turn, however, when Danny is exposed to a lethal neurological agent that presents an even greater threat: bio-terrorism on the island.