MacGarrett and Danny finally track down the missing uranium, which has been used to build a bomb located in the middle of the jungle. Now, they must carefully extract the unstable explosive through treacherous terrain before it detonates.

McGarrett and the team investigate when a deadly hit-and-run involves a driverless car carrying heroin, and what could be a new means for delivering drugs. Also, Tani and Quinn are stuck with a pair of YouTubers who are brought on a ride-along with Five-0.