Kate's southern belle of a cousin, Mae Belle Jennings, comes to Hooterville for an unexpected visit. Cousin Mae unintentionally causes problems between Floyd and Charley, who recently and happily celebrated their twenty-fifth anniversary of working together. The problem is that both men want to court her. They both will do whatever they can do earn her favor, even if it means breaking up their professional partnership and their friendship. Seeing what is happening between Charley and Floyd, Kate thinks she has a plan to bring the two friends back together, but Kate's plan worsens the matter. After having a chat with Cousin Mae, Kate turns to Plan B. But that almost backfires as well.

Kate's cousin Mae visits and tells everyone that with some backing from a wealthy banker, she plans on turning the Shady Rest into a health farm using a diet and exercise program called the "Mae Method Reducing Course". The only stipulation for the financing is that the banker's daughter, Agnes Bedford, has to lose fifteen pounds in two weeks using the method. However, Mae can't stay as she has to go back and deal with the banker, leaving Kate to work with Agnes. Uncle Joe is all for the idea until Kate tells him that he will be the male guinea pig of the Mae Method. Agnes, who loves her food, isn't the easiest person to convert to this new way of life. Kate, the girls and Uncle Joe's kindness towards Agnes doesn't help their cause. Mae returns with a new scheme for the hotel.

Life at the Shady Rest is going well despite Kate's absence. The girls and Uncle Joe receive a letter from Cousin Mae who is planning on coming by to take charge. Cousin Mae's meddling quickly wreaks havoc for everyone. This includes the hotel's relationship with Drucker's Store, Steve and Betty Jo's remodeling plan for the cottage, Bobbie Jo's love life with Jeff and Billie Jo's singing career. Fortunately, sane and stable Aunt Helen arrives. As Helen too ends up a victim of Mae's meddling, she comes up with a plan to convince Mae that her time at the Shady Rest is at its end.