The US government wants to cut over $3 billion out of the science budget, and NORBAC has to prove they deserve to stay in operation. Meanwhile, a West Nile like virus is breaking out in San Francisco, but it's showing some abnormal traits. A scientist at the University of Toronto claims to be able to help Owen with his addiction.

Mayko finds the missing link to the Sinatra syndrome; Owen tries to commit suicide.

The team traces the Sinatra virus to an organ donor in the Philippines; David blames himself for allowing Owen to try experimental gene therapy to cure his drug addiction.