Cesare's renegade generals mount a rebellion against him, while those close to Rodrigo conspire against him, all on the eve of Lucrezia's wedding.

Lucrezia meets her new family with mixed results, while at home a malaria outbreak has historic consequences for the Borgias.

Rodrigo's death sets chaos in motion on many fronts and forces Cesare to practice his most sophisticated politics yet as stakes are raised.

With a new pope crowned and order breaking down, Cesare finds himself with more and stronger enemies than ever.

Cesare is brought to La Mancha and goes on trial before the Inquisition, while Lucrezia must use extreme measures to save her marriage.

Cesare's ultimate judgment is realized while Lucrezia struggles to make sense of her family's history and its future.