Six months have passed since Brian left town following a heartbreaking blow out with Marjorie, the current love of his life -- who also happens to be engaged to Brian's best friend, Adam. Dave and Deena, have been suffering the fallout of their disastrous experiment with an open marriage. Meanwhile Brian's sister, Nicole, is thrilled to finally be pregnant, but unfortunately she's doing most of the nesting alone, since her husband is off in Rome starring in his first film.

To encourage each other to get over Marjorie and back out in the dating game, Brian and Adam bet to see who can get a girl first. Meanwhile, Brian adjusts to having Dave as his new roommate after Deena kicks him out of the house for having an affair; Nicole prepares for her baby shower, as well as a surprise guest; and the future of Zap Monkey is in jeopardy, which causes a financially-strapped Brian to try anything and everything to save the company.