The story begins with our heroine Yuu Morisawa watching the Feather Star descend for a landing oblivious to the hefty workload at the crepe shop that her parents Natsume and Tetsuo are desperately trying to resolve on their own; a clumsy stumble into her childhood friends Toshio Ootomo and Midori Kisaragi later, the panicked Yuu votes with her feet using Tetsuo's scooter into a frenzied pursuit sequence whose zenith is four police cars and a helicopter along with Toshio on a bike. Oblivious to the chaos that she has caused with her mad dash through town, Yuu is enthralled with the Feather Star as it comes in for a landing; upon learning that she can see the Feather Star, the two alien cats Posi and Nega draw Yuu aboard where there is a dysphoric fantasy dream sequence that gives way to an encounter with the grateful alien Pino-Pino. Having some family government imparted at the breech upon arriving home sets the stage for the ultimate silver lining of Yuu finding that Natsume and Tetsuo are not hostile to housing the two alien felines who later lead her through utilizing her new-found magical powers; after some cryptic and perplexing trial and error, Yuu successfully initiates her first henshin into Creamy Mami.

Toshio's efforts to temper Midori's expectations of spending time with Yuu obfuscate the fact that Yuu herself is grappling with the disadvantages of being Creamy Mami -- the greatest of which is the narcissistic and fanatical Shingo Tachibana hell-bent on making Mami a star with his company as he orders his staff to find her. The panic Yuu is driven into at the sight of Toshio explaining Shingo his recent encounters with Creamy Mami while Midori tries to steal lustful glances at her illustrates the immense contention that Yuu undergoes as she tries to keep her double life as Creamy Mami a secret although Tetsuo and Natsume are picking up some piecemeal clues; nevertheless, Yuu unwisely decides to »debut« before Toshio so that she can explain things and nudge him toward the rest of his life but is shocked to find that Shingo has other ideas and is not taking no for an answer. Facing the backdrop of Shingo and Megumi ultimately having made the choice for her, Creamy Mami begins her career at Parthenon Productions in earnest.

Parthenon Productions receiving a heartfelt letter from a boy named Kenji facing a surgery that could prove just as deadly as the disease it is meant to treat tugs on Hayato's heartstrings while Shingo sees it as a professional opportunity as he charges Hayato a schedule change for Creamy Mami. The convoy of news vans provides Kenji the perfect excuse to go investigate the hullabaloo with his derisive neighbors; while Yuu tries to give her swim coach the slip after Midori intercedes for her, the actual situation is demonstrated to be somewhat more complex than meets the eye when it turns out that it is Kenji's yakuza grandfather Tamegoro Zenigami that needs the pep talk. Shingo and Hayato have quite the imbroglio on their hands: it is a public relations disaster if it is argued they have ties to the yakuza and also if they spurn a young boy's entreaty for assistance because of what he was born into. While the mirage Creamy Mami leads Kenji and Shingo through takes care of the other reporters, the tabloid reporter known as Snake Joe is not so easily dispatched. Snake Joe's attempt to pervert Creamy Mami's humanitarian compassion to his professional advantage becomes the forum for Kenji's former detractors to ultimately show their true colors after Mami asserts her innocence; a telekinetic juggling act from Posi and Nega instigates Snake Joe's retreat and Tamegoro's successful recovery.