Can anyone run a marathon? How do you run 26.2 miles if you have trouble making it around the block? With good coaching, discipline, and lots of group support, as NOVA shows when it follows 13 generally sedentary people through a training regimen designed to prepare them for an ultimate test of stamina and endurance. Produced in cooperation with the Boston Athletic Association®, which granted NOVA unprecedented access to the 111th Boston Marathon®, and Tufts University, "Marathon Challenge" takes viewers on a unique adventure inside the human body, tracking the physiological changes that exercise can bring about.

"Making Stuff: Smarter" looks at materials that respond to their environments and even learn, such as an airplane wing that changes shape as it flies. Scientists are turning to nature in developing such "smart" stuff. Sharkskin, for instance, has inspired a substance that, when sprayed in hospitals, could eliminate antibiotic-resistant bacteria. David Pogue visits a scientist who has even created a material that can render objects invisible. "Smarter" concludes with a vision of the ultimate in "life-like" stuff: programmable matter that could create a duplicate of a human being.

What happens when scientists open up nature's toolbox? In "Making Stuff Wilder," David Pogue explores bold new innovations inspired by the Earth's greatest inventor, life itself. From robotic "mules" and "cheetahs" for the military, to fabrics born out of fish slime, host David Pogue travels the globe to find the world’s wildest new inventions and technologies. It is a journey that sees today's microbes turned into tomorrow’s metallurgists, viruses building batteries, and ideas that change not just the stuff we make, but the way we make our stuff. As we develop our own new technologies, what can we learn from billions of years of nature’s research?