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Black Jack's father contacts him for the first time in 21 years and asks Black Jack to perform plastic surgery on his second wife. Black Jack, still holding a grudge on his father for walking out on him and his mother when they were injured in a bombing, does the surgery under the instructions to make the woman "The most beautiful woman alive." Black Jack constructs her face to look like his late mothers. After he arrives at his house, a bomb detonates, much in the same way that happened to him when he was a boy.

Black Jack and Pinoco go to a middle eastern town after leaving the damaged Sky Hospital. While there, Black Jack is arrested and accused of murder. He is cleared of the charges thanks to a Japanese businessman named Aritani. Black Jack makes an agreement with Aritani, saying that he would repay the favor. Later, Aritani is convinced to take the fall for his company which was funneling money illegally. After claiming to be responsible for the dirty play, Aritani is thrown in front of a train in an assassination attempt disguised as a murder. Desperate to save Aritani's life, Black Jack uses some of his savings to buy out the hospital Aritani was being kept at after he inspires the proper owner with his determination. Black Jack saves Aritani and receives his first real lead on the group after his life.