Three baby boys are born on a stagecoach that arrives in Dodge just after being robbed. Their mother dies and Doc fights to keep the boys together instead of going to an orphange.

While Matt is out of town tracking outlaws, the cattleman's co-op takes over the town putting their own man in charge of the law.

A teenage burglar involved in a murder is shot and left to die by his partners.

The father of a young gunfighter tries to end his son's career by wounding his gun hand.

Hillbilly girl Merry Florene comes to town to get some schooling to better herself. Meanwhile her two cousins also arrive in Dodge and force her to rob Mr. Jonas' store.

Durning a drought, a watch witch (someone who can find water), comes to town. Meanwhile, a businessman attempts to buy up farms during this time, no matter the method.

Grant Lyle, a former lawman with crippled hands, brings his young gunfighter son to Dodge to settle the score with Hoxey, the man just released from prison who is responsible for his hands.

A comedic episode. Two hillbillies attempt to turn their 102 year-old relative in for the bounty on him.

Leary O'Quillan kills a card cheat in self defense and is pursued to Dodge by the man's brother, Clay Tynan.

Matt clashes with maverick railroad builder Wes Cameron and his wild men running a railroad line through Dodge.

Newly intervenes when two bounty hunters try to kill a desperado who claims he's innocent.

When he is refused a loan by the bank, Ray Jarvis' children find a way to steal the money.

A former girlfriend of Matt's provides a link with catching a notorious killer.

Will Mannon, a sharpshooter who rode with Quantrill's Raiders, terrorizes Dodge City as he waits for Matt to return and face him in a showdown.

A scholarly man in Dodge is actually a former commandant of a Civil War prison camp.

Doc is given the choice of saving the life of a man he saw commit a murder and delivering a baby. He choses to save the man first, and the baby dies in childbirth. The baby's father, Tom Butler blames Doc and plans to get even.

Three bounty hunters hold hostages in the Long Branch to get Matt to turn over a prisoner to them.

A friend of Matt's, a former lawman arrives in Dodge to kill the men responsible for his wife's death.

Ma Colter tries to dissuade her youngest son from following his older brothers into a life of crime.

A hidecutter starts trouble in the Long Branch and Matt comes to the rescue throwing him out of town. When Festus goes up to fetch Dr. Chapman, he finds the old scudder there himself. Offering to buy Doc a drink, he can't resist and they surprise everyone down at the Long Branch. While they are all excited to see Doc, Matt is out checking the town and ends up shot in the back by the hidecutter he just threw out. Doc's homecoming is ruined when he realizes that if he tries to remove the bullet he could paralyze Matt and he doesn't want to be the one to do it. So, he contacts a surgeon in Denver, and loading Matt in the baggage car of the train, Kitty, Doc, Festus, and Newly all head for Denver along with a Federal gold shipment.

As the train moves along to Denver we meet several passengers. One is a Pinkerton man handcuffed to Beth Tilton, a woman who doesn't want to go back to Colorado to her husband. The other, Allie Dawson, is a young girl that Newly befriends who does not believe in violence. The train is taken over by Jack Sinclair, an old enemy of Matt's. Matt had shot his hand off before sending him to prison. Making it look like Matt is a dead body in the baggage car, he is safe for now with Doc standing guard, but it can't last long. Kitty senses trouble when Beth starts cozying up to Jack Sinclair and worries she'll tell him what she knows. Warning her that she'll do anything for her man, Kitty watches Beth like a hawk. Festus and Newly are forced to help load the gold shipment on the wagon and when they get it loaded they end up driving off with it luring the gang out on foot to chase them. Beth tells one of the guards about Dillon in the back, and he goes to kill him.

The conclusion to this three parter. Dillon kills the guard that was gunning for him and the passengers take the train back over. The only problem, all the fuel has been destroyed so they have to get more fast. Festus and Newly are still out with the gold leading the men from the train on foot. Dillon's legs are numb and Doc has no choice but to operate whether he cripples him or not. Leaving the gold shipment and taking the mules, Newly and Festus head back to the train to try to get it going. Sinclair has the men push the wagon back to the train and gets there in time to keep it from taking off. Beth tells Sinclair about Matt Dillon, but Dillon's faster than a gun even lying down and ends up killing him. The train takes off leaving the bad guys and all their gold sitting at the tracks with no way to get anywhere.

A guy comes to Dodge for revenge on a guy who might just deserve it.

Two outlaws head back to Dodge City to visit their mother who doesn't trust her son's. Who claim to want to work the farm and take care of their mother. They intend to take their mother's money along with Doc.