Sean drinks to a great extent as he spends a depressing Christmas without his family; Christian gets an surprising gift when a 3-year old Wilber comes back into his life; and James pressures Michelle to help as she takes forceful measures to fill her holiday kidney quota.

Sean contrives to sell his portion of the practice; Michelle's connection with James finally ends, but not with James' boss; Gina is not happy to discover about Michelle's role in Wilbur's life; Matt tries to rekindle the spark with Kimber; and Poppy and Liz break up.

Sean and Christian have relocated their practice from Miami to Los Angeles. Being new to the city they find themselves having to start from scratch business wise. What they thought would naturally fall into place turns out to require some foot work. So Christian and Sean hit the town and begin discovering a whole new world.

Sean discovers the secret between Christian and Julia. A hospitalized Matt bonds with his rehabilitation counselor. Eden suspiciously makes peace with Julia. Kimber and Ram reveal their future plans.

Christian attempts to cope in the aftermath of a death. Colleen feels threatened when another talent agency shows an interest in Sean's acting career.

After being rejected by Kimber on account of his post-surgery scars and with his chemotherapy making him sick, Christian seeks support from Liz, which leads to a surprising sexual encounter between them. Sean discovers his new lover (Jaime Ray Newman) has a disturbing fetish, and further alienates Julia and Matt when they learn that he has been faking his need for a wheelchair. Raj has a life-altering sexual encounter with the wife (Beth Gargan) of McNamara/Troy's latest patient.

Sean tries to deal with his feelings for Julia, while Liz and Christian analyze their relationship and Christian meets someone who understands what he is experiencing with his breast cancer.

Christian decides to employ Dr. Logan Taper for the practice, while Sean is revisited by a former client from Miami to have plastic surgery so she can attract suitors once her husband dies.

As Christian and Liz make their wedding plans, he also looks for a new cancer treatment. Meanwhile, Ram Peters drops Kimber for a newer model, while Teddy informs Sean that someone close to her is gone, and Sean and Christian repair a couples neck wounds which look strikingly similar at McNamara/Troy.

As Season 6 begins, Christian has news for Liz and the economic downturn has hit McNamara/Troy hard. But the boys might have found a lifesaver in Dr. Mike Hamoui (Mario Lopez), who's now in L.A. and has found a very profitable niche specialty. Meanwhile, Sean's relationship with Teddy Rowe (now played by Rose McGowan) has blossomed, and Matt, who's down on his luck, takes up mime.

Sean experiences an ethical and moral dilemma when McNamara/Troy is requested to perform a surgical procedure on a prison inmate. Kimber questions how far she will go to keep Christian when they receive life-changing news.

Sean and Christian reflect on their relationship. They also remove a scar from an elderly Japanese man and have a surprise for Liz. Meanwhile, Christian makes a deal with Ava.