While being pursued by the Enforcers, Spider-Man has to protect Norman Osborn from the vengeful supervillain Vulture.

When a lab accident transforms Max Dillon into supervillain Electro, he demands that Dr. Martha Connors find a cure as Spider-Man works to stop him.

When. Dr. Curt Connors' attempt to regenerate a new arm accidentally transforms him into the Lizard, Peter, Martha, Eddie and Gwen search for a cure.

Following orders from Kingpin, Hammerhead hires Montana to steal a high-tech suit and, as the Shocker, destroy Spider-Man.

As Peter Parker and Harry Osborn try out for the football team, Spider-Man must face convict Flint Marko, newly transformed into the Sandman in order to destroy Spider-Man.

As Otto creates the Rhino as a new distraction for Spider-Man, Peter takes Aunt May's advice and asks Mary Jane Watson to the high school prom.

Disguised as Spider-Man, the Chameleon embarks on a crime spree that can only be stopped by Spidey and the Black Cat -- together.

When the Sinister Six escape from prison with plans to take down Spider-Man, they nearly succeed. But Peter wakes up with no memory of the battle.

As he struggles with the alien symbiote, Spider-Man's origins are revealed.

Venom -- the merged entity consisting of Eddie Brock and the symbiote -- attacks Spider-Man through the people he loves most.

Peter's "to do" list includes talking to Gwen Stacy about their first kiss. But before he gets a chance, Spider-Man has a run-in with Mysterio.

As Christmas approaches, the Sinister Six reconstitutes with Sandman, Rhino, Vulture, Electro and new members Mysterio and Kraven.

With the Master Planner and his henchmen planning to take over the world, a highly motivated Spider-Man takes the fight to the Planner's secret lair.

Peter and his loved ones become vulnerable to all of Spider-Man's enemies when Venom exposes Peter's secret identity.

On Valentine's Day, Tombstone, Doctor Octopus and Silvermane call a summit that erupts into a gang war -- one that only Spider-Man can stop.

When Peter breaks up with Liz to be with Gwen, nothing goes as planned. Likewise for Spider-Man, who finally unmasks the Green Goblin.