The headstrong investigator Georg Wilsberg meets Katharina again, his great love from school days. While he himself occasionally struggles to make ends meet, she is now happily married to her husband Matthias, mother of two children and owner of a magnificent city villa. Wilsberg is plagued by self-doubt: Has he made the right decisions in his life?

This time, the case seems very simple for the unorthodox private investigator: A young woman, Susanne Diepenbrock, commissions Georg Wilsberg to search for her missing sister Jessica. She suddenly disappeared and she cannot give a reason. But things are different with Wilsberg's best friend Manni.