A prison escapee returns to Portland and seeks revenge on everyone who got him arrested. Nick notices his unusual strength and high tolerance of pain and calls Monroe to help put his rampage to an end.

Nick and Hank are called to investigate the mysterious death of a wealthy matriarch, after her stepdaughter loses everything in a Ponzi scheme. Meanwhile, Juliette does some digging into the mysterious death of Nick’s parents in an effort to help him find closure.

As Nick and his mother continue to battle the Mauvais Dentes, Monroe and Rosalee (Bree Turner) fight against the clock to save Juliette. More details are revealed about the source of Juliette’s illness, resulting in an epic showdown. Back at the precinct, Hank senses that something is amiss when Nick lands in hot water with the FBI. Meanwhile, Captain Renard continues to reveal himself as he deals with his estranged brother.

After Nick learns about Juliette and Captain Renard, he must deal with the consequences. Things get even more complicated when Nick is called to investigate his own crime. Meanwhile, the search for the key intensifies as Captain Renard finds Nick’s trailer and makes a surprising alliance. With Rosalee’s help, Monroe informs Nick that they might be able to stop what’s going on with Renard and Juliette before it goes too far. Elsewhere, Wu responds to a bizarre shooting at Nick and Juliette’s house.

While on jury duty, Rosalee tasks Nick, Hank and Monroe to help stop a defense attorney from using his particular “Wesen wiles” to overturn what should be an open-and-shut murder case. Back at the precinct, Captain Renard brings Nick and Hank in on his own recent dealings with the Verrat, to keep them on their toes. Meanwhile, a return to the trailer brings a flurry of memories of Nick rushing back to Juliette.

As a deadly crime spree begins to surface, a century-old urban legend takes shape in Portland's sewers and becomes Nick's latest case. In Europe, Adalind meets Prince Viktor, who’s come to bring those responsible for his cousin Eric’s demise to justice. Meanwhile, Captain Renard responds to the recent attempt on his life.

Monroe fights an impossible battle to convince his parents to embrace the life choices he’s made. Meanwhile, Nick turns to Juliette to help him figure out the Wesen aspect of his cop-killing scalper investigation. On the Royal Baby front, Captain Renard learns new information that forces him to contact Adalind in the interest of keeping her and the baby safe from Viktor.

Nick and his mom, Kelly Burkhardt, join forces to protect Adalind's baby. Meanwhile, Prince Viktor activates a deadly stateside asset to find Adalind and her child.

The Gedächtnis Esser continues to steal memories and Captain Renard's mother visits him in the hospital to try to save his life. Meanwhile Wu confronts Nick about Trubel and Nick and Adalind share a psychic connection.

Nick and Hank investigate a murder victim with his foot cut off, and stumble onto a disturbing Wesen take on the "lucky rabbit’s foot." In an effort to help, Monroe and Rosalee go undercover. Meanwhile, the fallout from Adalind and Juliette’s showdown still has Nick reeling and sends him on a path that leads to Henrietta.

A string of homicides have the press asking Captain Renard if a Jack the Ripper copycat has arrived in Portland. While dealing with the investigation, Nick, Hank, Monroe and Wu deal with a situation they never expected. Meanwhile, Adalind and Rosalee must work together on a last ditch attempt to fix Juliette's condition. Elsewhere, Juliette decides to help her new ally even if it means hurting those around her.

Suffering from the bite he sustained, Sargeant Wu becomes entangled in a surprising altercation that may land him in hot water. After meeting the mysterious Bonaparte, Adalind is faced with a difficult decision that could change her and Nick's lives forever. Meanwhile, Hank gets even closer to Zuri and their relationship begins to take shape. Back at HW, Eve senses that a new force may jeopardize the entire operation.

Eve goes on a mission to take on the mysterious force she saw in the mirror and finds herself in unfamiliar territory. When the gang discovers what she has done, Nick finds a way to join her. Meanwhile, an uneasy alliance is established when Capt. Renard is brought in to help and discovers this all may be connected to the person he cares for the most, Diana.