Wilfred is angry after Ryan tricks him into going to the veterinarian.

Wilfred persuades Ryan to help him get rid of Jenna’s boyfriend.

Just as Ryan finds happiness in his life, Wilfred begs him to sacrifice it for a larger purpose.

A crisis arises when Ryan ignores Wilfred's advice.

Ryan learns that life is much more challenging without Wilfred around.

When Wilfred comes to the conclusion Ryan is the only beneficiary of their friendship, he denies Ryan any further help.

Wilfred muddles Ryan's plan to introduce Amanda to Jenna.

Wilfred derails Jenna and Drew's wedding because of Ryan's jealousy.

In the second-season finale, existential questions are posed to Wilfred and Ryan.

Ryan befriends Wilfred’s enemy—the mailman.

Wilfred pursues a forbidden love.

Ryan is put in danger as Wilfred pursues the path to valor.

Season 3 ends with Jenna forbidding Ryan from seeing Wilfred when he needs him most.

Disaster strikes when Ryan and Wilfred get an unwanted guest on their camping trip.

Ryan fears a future without Wilfred, as his battle with cancer becomes more severe. Drew returns from Wisconsin.