When the FBI takes on a case of disappearing college girls, Jack Crawford recruits Will Graham, a gifted criminal profiler with a unique view into the psyche of serial killers, to consult. Jack also seeks the help of Dr. Hannibal Lecter, a brilliant psychiatrist. After a copycat strikes, Will and Hannibal join forces to track down the culprit.

Abigail Hobbs comes out of her coma with new information about her father.

Hannibal frames Will, convincing Jack and Alana that Will's the copycat killer.

Will and Margot hide her pregnancy from Mason. After Freddie's gruesome murder, Alana's doubts about Will and Hannibal grow stronger.

Springing their trap, Jack, Will and Alana face off with Hannibal in a bloody final showdown, but the doctor has a few surprises of his own.