While on their vacations, each of the team receives a clue from a psychopathic killer challenging them to save his next victim.

When the prolific serial killer Frank returns and murders Gideon's girlfriend, Gideon takes off to find him without telling the team where he is going. The BAU must then profile Gideon as well as Frank to find both of them.

In Milwaukee, a series of women have been found murdered with their hearts crudely removed. The BAU is assigned to the case, but they are short three members: Gideon, who is missing, Hotch, who is on suspension and Prentiss, who resigns her commission to join the Foreign Service. Supervisor Strauss steps in as lead, but she doesn't handle herself well in the field.

The BAU and local authorities in Los Angeles investigate gang-related serial killings that might possibly involve a famous comic book artist.

Rossi travels to Indianapolis to continue his investigation into the two unsolved murders that have plagued him for 20 years.

When an SUV carrying members of the team explodes, the rest of the team fights to save them and catch the terrorists responsible for the bombing.

Agent Prentiss has a personal connection to one of the victims in a series of deaths with religious overtones.

The BAU tracks a serial killer who chooses junkies, prostitutes and the homeless off the streets of Detroit as his victims and takes them across the border into Canada, and an agent's life is in peril.

The BAU team races to help Hotchner find The Reaper and save his family before it's too late.

A series of rolling blackouts in the city of Los Angeles lures a serial killer out of hiding, giving him renewed opportunities to continue his killing spree.

The BAU team closes in on the serial killer as he continues his murder spree throughout Los Angeles - with Detective Spicer's kidnapped daughter as his hostage - in the conclusion of last season's cliffhanger.

The members of the BAU enjoy a Saturday off in vastly different ways. While Rossi and Prentiss help Simmons assemble a new crib, Garcia leads a hacking competition, and Dr. Reid strikes up a conversation with a woman named Maxine.