The BAU team travels to Mexico to aid in the capture of a serial killer who is targeting elderly women.

The investigation turns to the family as the BAU and local authorities race against time to locate a young girl who has disappeared from a local shopping mall.

As Hotch fights for his life due to complications from his stabbing at the hands of George Foyet, a.k.a. "The Reaper," he experiences visions of his late wife, Haley, and his nemesis, Foyet. Meanwhile, the BAU searches for a missing teenager and investigate her estranged father as a suspect in her disappearance.