The BAU is called to investigate a series of deaths in Virginia suspected by the Center for Disease Control to be caused by bio-terrorism; Garcia visits her stepbrother to take care of a family issue.

The BAU steps in to help local law enforcement isolate a prime suspect for a ritualistic murder in Tallahassee, Fla., and soon after a second person who is related to the first victim is killed under similar circumstances. Prentiss is concerned about Garcia’s behavior in the aftermath of her abduction and has an idea of how to help with the healing process.