Scully and Mulder investigate when an art gallery displaying offensive artwork is bombed, and need to discover a way to communicate with the comatose perpetrator to try and prevent a future attack.

The season concludes with people all across the country falling gravely ill. A widespread panic develops and Scully looks within to find a cure. Meanwhile, Mulder confronts the man he believes to be behind it all, but another figure from Mulder and Scully's past may prove to be the key to their salvation.

Mulder and Scully learn that they aren't the only ones desperately searching for their long-lost son, William. The very fate of the world may depend on it.