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Pietro, while quelling a fight on a construction site, discovers the charred corpse of a young woman: the investigators of Sant'Andrea must identify the victim with a piercing and a gunshot wound as the only clues. In Barcelona, ​​the boss Paternò, worried about the disappearance of his daughter Marina, decides to take action by leaving for the capital of Naples.

The body of a woman killed by a gunshot is found in an area frequented by prostitutes: the autopsy reveals that the victim was a nun. Matrone informs Paternò that De Giovanni ordered the murder of his daughter, so Paternò plans revenge. At Sant'Andrea the wedding of agent Santoni is celebrated, but the party ends in tragedy with a shootout.

While Commissioner Pettenella investigates who killed Paternò's daughter, Sciacca fears revenge for not having helped him. A fear that could be confirmed by the discovery of the lifeless body of a girl, the niece of an affiliate of De Giovanni. The agents are also investigating the murder of a young clerk with ties to the loan shark environment.

The discovery of a child's skeleton in a farmhouse reopens a ten-year-old unsolved case: Silla shows the evidence to Pietro, provoking an intense reaction. Despite Cafasso's opposition, Pietro decides to investigate privately. Meanwhile, Antonio and Giulia are faced with a complicated eviction that reveals a trafficking ring of counterfeit goods. In the darkness of his search, Sciacca desperately searches for his missing woman, ignoring the rules to save her life.

A boat explodes, carrying the body of an old sailor onto the reef. The initial hypotheses of an accident are discarded by the autopsy: it could have been an attack. Sciacca, worried about Silvia, asks Pettenella for help. Cafasso presents Sciacca with a choice: if he wants to continue following the case, he must accept Ramaglia's supervision.

A woman is unable to enter her apartment. Demetrio and Giulia find her husband dead, apparently struck by lightning. Sciacca, devastated by Silvia's death, is removed from the investigation and the only person who manages to reach him, despite his desperation, is Pettenella, the most cynical of the men of Sant'Andrea.

The death of a seventy-year-old woman found in her apartment leads Antonio and Francesco to investigate. Meanwhile, Cafasso, to avoid leaving Sciacca to the ghosts of the past, entrusts him with the management of the archive. A complaint for vandalism leads the agents of the Squadra to discover an illegal traffic of disability permits.

A fire due to an explosion in a building causes the death of a woman and scares Lepre to death, who fears a plot against him. Pettenella tells Sciacca that Bonanno is willing to collaborate, but Salvatore is convinced that it is all a bluff. Ivan manages to escape and, despite being wounded, reach Tania, who, confused, confides in Stefano.

The son of the PM Menale mysteriously disappears and the team suspects a criminal sentenced by the magistrate, who has just escaped from prison. In the meantime, at the foot of an abandoned farmhouse, the body of a girl with traces of lethal chemical substances is found: with the help of Dr. Salibra, the men of Sant' Andrea try to understand what happened. Pettenella takes over the management of the police station in the absence of Cafasso, who left for the East. After a night with Berti, Anna is in internal conflict and decides to follow her instinct.

After a failed ambush, De Giovanni is in the hospital seriously injured; his clan, determined to take revenge, exterminates the family of Matrone's right-hand man, unleashing a war. A woman sees the killers, but while running away she loses a shoe that will become crucial to the investigation. At the same time, a theft of precious coins and the disappearance of Fernando Vacui further complicate the situation.

Francesco and Demetrio find the body of a woman in the trunk of a stolen car, with no correspondence in the missing persons reports. The case thickens when the body of a boy is also found: the only clue for the men of Sant'Andrea is a portrait with the stamp of an art academy. A new agent, Laura Rotunno, joins the Squad. In the meantime, the murderer of Paterno's daughter dies in prison.

With Cafasso's return from the East, investigations reveal that the Camorra was using a Chinese port to export toxic waste to Asia. Alfio and Patty, taking a short vacation, suddenly end up in the delivery room.

After the death of the mafia boss Paternò, the Sant'Andrea department faces new challenges: Inspector Claudio Martusciello captures a drug addict who robbed an elderly woman, but does not appear in court to testify. They discover that someone has taken his identity. In the meantime, a headless man is found and a Somali girl mysteriously disappears. The mother confesses to having hidden her to save her from infibulation, but the child has disappeared. Francesco Silla, seeing his father with another woman, decides to leave his grandfather's house in Piazzetta Viviani.

A medium reveals to the press the location of the body of a businesswoman who has been missing for two years at the bottom of a lake. Her husband, with photos taken by a diver, asks to reopen the case. Cafasso and Pettenella find the car and the body in the indicated location. The autopsy excludes drowning, confirming murder. The investigation focuses on the victim's family and collaborators, revealing a complex picture of rivalries and tensions that include a fired employee, her husband and children.

Following a tragic car accident, a man's body is pulled from the wreckage. Initial investigations reveal that he is Matarazzo's assistant. When he returns home, the detective finds his apartment in disarray and receives a threatening phone call. In another story, Francesco discovers the involvement of a friend's brother in a theft with a particular motorcycle. Meanwhile, Anna continues to lie to her husband to hide a secret relationship.

A boy is beaten bloody by some thugs who disappear into the night. A friend promptly helps him but the two have placed a bomb in a construction site to prevent its construction. A full-scale investigation begins and Pettenella discovers that the engineer in charge of the project hides a not-so-sharp past. In a supermarket parking lot Giulia witnesses an accident involving two elderly people, the perpetrators of an alleged deception.

An engineer and a no-global protester lose their lives in a deadly ambush. Ramaglia, who rushed to the scene, is suspected of shooting the protester, sparking urgent investigations to establish his responsibility. The Squadra investigates the involvement of the engineer and the possible instigators, with the Camorra as the main suspect. The discovery of an architect's body mysteriously links the victims. Francesco settles in Piazzetta Viviani, while Anna seeks justice for her sister's death.

A manager of an armored car agency surprises three robbers in his kitchen who threaten to kill his wife and daughter. After emptying the safes, the criminals flee. The Squad intervenes promptly, finding the family unharmed in their garage. Meanwhile, a graphic design studio reports a murder and a gas station reports a mysterious disappearance, linked by traces of blood that lead to new disturbing discoveries.

The Squad investigates the death of a missing girl, found in the woods. Was it an accident or a murder? The autopsy reveals a miscarriage as the cause of death. Who was the girl? Who were her friends and the person responsible for the pregnancy? Michele Paglietta, her boyfriend, denies killing her. Sciacca, watching videos from a gas station, notices a suspicious blue station wagon among the parked cars.

The Squad continues the investigation into the death of Patrizia De Simone. Antonio and Demetrio go to the home of Domenico Grandi, who is lying face down on the ground. Next to him, a gun. Meanwhile, the body of an unidentified sailor is found at sea, with only a photo of a young girl.

Dr. Miriam Girelli, a famous notary, calls Sant'Andrea confessing to having killed a thief in self-defense. Walter, Sciacca, Nicoletta and Dr. Mari find the body in the villa with a necklace and a gun next to it. The husband reveals that the victim was a member of the squash club. There are no signs of forced entry, but the thief has disappeared from the security footage.

A new mix of cocaine and chemicals is tested on regular users. Sciacca, Laura and Dr. Salibra interrogate a dealer to get the name of the supplier, but without success. Alfio receives a dose of cocaine and a note with a sequence of numbers and letters that Walter and Anna discover to be the code for a container with 100 kg of cocaine for the boss Annibale Ruotolo. Kevin Inzerillo, an old acquaintance of Salibra, is involved. The doctor decides to investigate on her own.

Synthetic cocaine invades Naples. Santo Cosenza, linked to trafficking, has disappeared, jeopardizing the confrontation with the boss Annibale Ruotolo. Pettenella's phone, authorized for control, is not giving signals. Adrianne Ledger, under investigation, has disappeared; Cosenza's fingerprints in her apartment provide a lead. Sciacca, Anna and Demetrio investigate a robbery that took place in a villa where drugs were found.

The Squad continues the hunt for Adrienne Ledger. Inside a refinery they find a charred corpse with clues that seem to link the accident to Annibale Ruotolo, but the investigations lead to discover that it is a red herring. A boy with a small criminal record for drug possession is found dead. The victim knew Dr. Salibra's son. Antonio investigates the disappearance of a student in Tirana who may have come to Italy for a relationship with a student from Naples met in chat. Pettenella, for the first time, feels the weight of responsibility on her shoulders and runs away, avoiding any meeting with her nephew Joe.

In the countryside near Naples, the Squadra investigates the death of a woman in a farmhouse. Pietro, Sciacca, Laura and Walter are confronted with conflicting testimonies: traces of the missing partner's blood further complicate the case. Meanwhile, the men of Sant'Andrea face an expert thief who continues to rob taxi drivers, always managing to escape.

The body of a girl from Naples' upper class is found on a beach in the city. Only one clue: on the victim's cell phone, a message from her boyfriend who arranged to meet her in that place. When questioned by Pietro, the boy says he knows nothing about the message, that he has lost his cell phone and that he has an alibi: at the time of the murder, he was at a soccer game with friends.

The day after the violent explosion at Sant'Andrea, the policemen share a deep sorrow and the angry desire to capture the person responsible. The question arises about the true identity of the accountant who died in the terrible ambush together with the group of criminals who infiltrated to free him, what facts did he know?

An elderly man arrives at the police station to report the discovery of a fanny pack containing a lot of money and a notebook with indecipherable notes. Alfio and Antonio discover that the man is an internationally renowned university professor and immediately speak to Cafasso. What is the relationship between an apparently honest professor and the Camorra?

A blood-stained bedroom, the lifeless bodies of a man and a woman, a new complicated case for the agents of the Sant' Andrea police station. At the crime scene there is no sign of violation, but the killer left his traces on a protruding screw.

A boy who arrived in Naples from South America is taken to the emergency room for a serious illness. Sciacca and Silla, who rushed to the hospital, learn that the young man had cocaine pellets in his stomach and that, surprisingly, he asked to file a complaint.

A man is suddenly killed on the platform of a train station just before the arrival of the train he was waiting for. Dr. Veneziani, who rushed to the scene of the murder together with Sciacca and De Luca, finds a briefcase containing a gun.

After the discovery of the body of a man of Chinese origin, Dr. Veneziani begins the investigation at the crime scene. Pettenella, Walter and Pietro think of a possible war between the Camorra and the Chinese mafia. All possible investigative leads must be pursued and Anna tries to investigate what is happening within the Chinese community.

A man lies lifeless on the ground with scissors stuck in his throat, a possible macabre signal sent by the Camorra to indicate that he had talked too much and therefore deserved that tragic end. Walter, arriving at the scene of the murder, recognizes his informant: the tailor Ilario Bigi.

Having entered the lair of the boss Annibale Ruotolo, the police find that the apartment is empty and there is no trace of the Camorrista. Did the boss understand what their plan was or is there a mole who has spilled the beans? Someone made Anna disappear, who recently pretended to be a corrupt policewoman to allow our men to capture Ruotolo.

A young boy, who Antonio helped in the past to get out of the drug scene and who joined an association for the recovery of young people at risk, goes to the police station to ask for help: his stepfather, a criminal with violent behavior, has been released from prison thanks to a pardon and now represents a threat to him.

The investigations continue to capture the boss Annibale Ruotolo. After discovering that the ambush set on Ruotolo two years earlier was organized by Vincenzo Matrone, an old acquaintance of Sant' Andrea, the new vice-questor Tiziana Torre and the commissioner Pettenella ask the magistrate for authorization to meet the young Camorrista in prison.

While Cafasso and the men of the Bellini police station are still at sea with the investigation into the murder of a black prostitute, a new crime similar to the first unexpectedly occurs. This time the agents of the Sant' Andrea are dealing with it: a Nigerian prostitute, killed with two shots to the heart, lies motionless in the arms of a boy who does not want to separate from her.

The men of Sant'Andrea and those of the Bellini police station, led by Cafasso, continue to investigate the deaths of Nigerian prostitutes, their pimps and their customer base. The prime suspect in the murders, however, is found dead in his home. Dr. Mari's autopsy quickly reveals that the alleged serial killer did not commit suicide but was murdered.

Mafia boss Vincenzo Matrone has escaped from the rehabilitation clinic where he was hospitalized. A young policeman, the only guard on duty for the boss at the time of his disappearance, becomes the scapegoat because he had left the room for a few minutes in order to help a nurse dealing with a woman in a coma.

Antonio and Demetrio question the colleagues of a worker who fell from a scaffolding at the port and who is now hospitalized in serious conditions. No one knows why the worker was up there and there appear to be no witnesses to the accident. The investigators suspect an attempted suicide to collect the insurance, the doctors find a wound to the man's head caused by a metal edge.

Following the failure of an important operation, Cafasso is convinced that the mole hidden in the Bellini police station is Commissioner Livia Palma. In fact, a call was made from her phone to a mysterious cell phone, registered to a dead man. A number activated immediately after the escape of the boss Vincenzo Matrone.

A fire breaks out in an illegal parking lot, among the cars on fire is that of the manager of a private company that manages the water supply. The Sant'Andrea agents discover from the bank records that the woman regularly pays protection money and near the manager's office the body of a worker is found.

The men of Sant'Andrea are dealing with a raid inside a nightclub. After intercepting some drug dealings and guarding the entrances to the club, the policemen move on to searches. Among the many young people stopped and taken to the police station, there is a student who reacts desperately: a small bag of cocaine was found in her bag and she declares that she does not know who could have put it.

The body of a girl is found in the waters of a canal. No documents, no signs that could lead to her identity. A young man, recognizing the photo in the newspaper, reveals to the men of the investigation that he had met the victim the day before. She was an Argentine journalist who intended to write an important investigation by collecting numerous testimonies.

A jeweler is robbed by two boys disguised as workers, impossible to trace their identities: the man was unable to see their faces. An interesting detail emerges from the surveillance cameras: one of the two robbers was wearing a cap with the logo of a yacht club. Ramaglia goes to the nautical club and discovers that among the young people of the reformatory who make clothing for the yacht club there are three old acquaintances of Sant'Andrea.

The lifeless body of a psychologist, a well-known university professor, is found in a peripheral area of ​​the city. Digging into his private life reveals a homosexual relationship with a young researcher. The boy, an old acquaintance of Simone, appears very willing to collaborate. The young man claims to have an alibi but this is not very reliable, therefore he is accused of the murder.

A well-known lawyer is robbed by a woman in a balaclava. A man catches a young boy in his apartment, and the same man is robbed a few hours later while walking down the street. The men on the team work to find a common denominator for all these crimes.

In the living room of a villa lie the bodies of three women with their throats cut: a mother, a daughter, and a neighbor. On the landing of the upper floor a man is fighting for his life, also in a pool of blood. No sign of forced entry and nothing to suggest an attempted theft.

At a bus stop a thief tries to snatch a purse from an elderly woman. Most of the bystanders pretend nothing is happening while a man, shocked by what is happening, confronts the criminal. With the assault report and the identikit obtained thanks to his testimony it will not be difficult for the men of Sant'Andrea to identify the thief.

During the dress rehearsal of a Neapolitan skit, a stage gun actually fires. The protagonist collapses lifeless on the ground and never gets up again. It is immediately clear that someone has replaced the fake gun with a real, loaded one. The investigation at the Sant'Andrea police station unfolds in an environment full of poison, intrigue and ambition.

Nine months have passed since the last investigation and in this time frame many balances have changed at Sant' Andrea. Deputy Commissioner Tiziana Torre has been transferred and Giorgio Pettenella, who has just been promoted, has returned to take her place. There is a familiar atmosphere and the police station seems to have finally regained its former harmony.