It's Luca Benvenuto's first day as coordinator of the 10th Tuscolano. The case is an assault on a couple. Meanwhile, Marco, Elena Argenti's brother, the new inspector of the district, finds himself in trouble due to gambling debts with the boss Luciano Gerace.

Irene is taken to the hospital in very serious conditions and the entire district gathers around her and Alessandro. Meanwhile, Luca organizes the search for the robbers. Raffaele and Elena, instead, must investigate the death of a boy, Antonio Servidei, whose body was found on a construction site.

Little Simone Fioroni is kidnapped from his mother Matilde's car. Meanwhile Alessandro continues his investigations into the robbery gang; following the trail of the car used by the robbers, which had been rigged, he arrives at a mechanic who is a potential accomplice of the criminals; to make him confess he risks going over the limit and is stopped by Luca, with whom he ends up arguing.

Alberta Tizzani was attacked in her home and helped by her neighbor Marcello; it is he who suggests to the men of the X° Tuscolano that, although the woman claims it was a theft, the culprit could be Cristiano, her husband, a domineering and violent man. Cristiano, however, denies everything.

A woman accuses her ex-husband of beating and raping her, but he denies it and for our men, faced with a web of hatred and lies, it becomes difficult to understand the truth. On the investigation side of the robbery gang, a glimmer of hope seems to open up: it seems that the gang will strike again soon. Our men prepare to surprise them on the spot.

After the disappointment of the failed operation to arrest the members of the robbery gang, a strange phone call takes our heroes to the scene of a murder. The victim is an acrobat thief who may have stepped on someone's toes. But by investigating the man's movements, another truth will emerge. Meanwhile, Alessandro, thanks to a case he stumbles upon, finally faces his grief and returns to Irene's grave.

The men of the 10th Tuscolano are on the trail of the Talicam technician who passed the gang the codes needed to carry out the robberies. In the meantime, a murder is committed in a call center and suspicion falls on one of the employees.

After the setback caused by the death of Talicam technician Ottavio Rinaldi, the men of the X° Tuscolano manage to trace a clandestine gambling den run by Camorrista Luciano Gerace.

While Luca follows the trail of Luciano Gerace's (Dante Palladino) Camorra clan, Alessandro, trusting his police instinct, decides to "hook up" Melissa. Meanwhile, the rest of the X° Tuscolano deals with the murder of a mother, in which the main suspect is the woman's stepson. The case is complicated by the fact that the only witness is the lady's biological son, an autistic boy with whom no one seems able to communicate.

While Luca perseveres on the trail of the Camorra, Alessandro (Enrico Silvestrin) continues to see Melissa in secret, putting his life at risk. The case of the episode instead concerns the alleged suicide of a woman no longer young suffering from cancer, whose "last journey" hides a much more disturbing truth.

After risking being killed, Alessandro involves his companions in the search for Melissa, which, in a crescendo of tension, ends with our friends falling into a trap set by the Flaviano brothers. During the episode, the murder of a construction site foreman is also investigated: what at first glance seems to be a simple case of revenge linked to accidental deaths at work, actually hides a much more complex scenario.

Having miraculously escaped the Flaviano attack, our heroes receive a tip from Melissa that leads to the discovery of the weapons used in the robbery in a warehouse in Gerace. The investigations therefore seem to be concluded, but Luca and his team still have doubts. Meanwhile, an investigation is being carried out into the murder of a pharmaceutical representative struggling with a financial hole in his company and two women, his current wife and his ex, who hate each other to death.

The men of the 10th Tuscolano are busy solving a case involving a young non-EU citizen. Thanks also to the help of Vittoria our men discover that Samira, the young woman, is the nanny of a family blackmailed by some loan sharks.

Anna and Raffaele deal with a case involving Alessia, raped a year earlier and now accused of taking revenge on the culprit.

Melissa's death triggers a deep crisis in the District. Especially in Alessandro, who feels responsible. After solving a mysterious murder case in which a fortune teller was the victim, however, news arrives that Melissa did not commit suicide: perhaps there is a clue to start again.

While Giulio Flaviano suffers from withdrawal, our heroes discover that the morphine used by Irene's killers is purchased thanks to a stolen prescription pad, therefore recognizable: they just have to wait for them to go back to do the "shopping". In the meantime, they have to solve the case of a girl who disappeared 12 years earlier and was found in a coma in a wood.

The inspectors of the 10th Tuscolano are dealing with a case involving a Muslim girl, Khadigia, beaten and repudiated by her husband Yusuf. Khadigia claims to have never been with a man and it will be up to Anna and Elena to understand what lies behind this mystery. In the meantime, Luca and Alessandro, who narrowly missed capturing Giulio Flaviano, are now convinced: there is a mole who informs the criminals of their every move.

The death of a twenty-year-old involves our team in a case with no apparent solution. Suspicions focus on the two roommates. Anna's brilliant intuition will reveal a much more bitter truth.

Alessandro drops by Elena's house. Alessandro discovers who really killed Irene... Marco, meanwhile, runs away. Luca has to take care of Nick, who has returned to Rome to see a friend of his and ends up entangled in a nasty story of drug trafficking.

The body of a taxi driver is found in a prostitution area. The investigation soon turns to the homosexual circuit. The revelation shocks the man's children, who did not know their father's true nature. Meanwhile, the Flavianos kidnap a woman. And to save her, Marco puts his own life at risk.

Her brother Marco is dead, but Elena can't forgive him for Irene's murder. And while the Flavianos are quietly enjoying the wait to complete the deal with Krueger, our heroes must solve the case of a surgeon accused of uxoricide, who loses his mind and takes Ingargiola and Elena hostage.

From a clue left by the Flavianos in their suite, Luca and his men finally manage to understand the ultimate goal of their plan: to get their hands on an illegal load of coltan, a precious mineral compound.

Thanks to Berti's incursion on Krueger's boat, our guys intercept the agreements between Gerace and the Flavianos, to intervene during the meeting between the boss and the Roman brothers. But first they have to face and solve a case that is close to everyone's heart: the former colleague Parmesan is accused of the murder of a loan shark.

Our team investigates the death of a woman. What appears to be an accident during sexual intercourse, takes on the appearance of a voluntary homicide, of which the woman's lover is suspected.

While the men of the X° Tuscolano prepare to celebrate Anna's wedding, they must solve a stalking case involving a young teacher. Meanwhile, a body that seems to be Valerio Flaviano is found in Perugia.

The film based on Ugo's book is ready. All of our people attend the preview except Elena, who disappeared without giving any explanation. Her colleagues are convinced that she was kidnapped.