Batman stops two vigilantes from taking their revenge over a shady land deal. An aging Alfred hires his replacement: a female bodyguard named Katana.

Ra's al Ghul recruits an army of Batman's foes (Professor Pyg, Mr. Toad, Magpie, Tobias Whale, Phosphorus Rex, and Cypher) in order to eliminate him.

Batman and Katana encounter a strange Man-Bat creature, who is the experimental result of Pyg and Toad's animal army of mutant humans.