Robbers lift a bundle from the Hargrove Finance Company and Frank Anderson is murdered in the aftermath. Anthony "Pop" Renzi is identified as one of the robbers and charged with both the robbery and the murder. Perry sets out to clear him of both charges.

Rhoda Reynolds is charged with murdering her blackmailing ex-husband, Arthur Kane. At the trial, Perry moves the proceedings to the room in which Kane was murdered in order to re-enact the fatal night.

A moonlighting school teacher is charged with the murder of a male acquaintence he had taken home after the acquaintence had earlier raised a disturbance at his night job at a cafe.

Playwright Ernest Royce is found shot to death in the same manner as a character in one of his unproduced plays. The play dealt with characters very close to real people and the real life murder of a New York underworld figure years before. Perry's client, Frank Brooks, is charged with Royce's murder and Perry must find the missing final act of the play in order to clear Brooks.

A double cross, a double murder, a plane crash, missing money, and yet another innocent widow charged with crimes she didn't commit are the elements of this case.

Crooked jewelry store owner Karl Addison learns that he needs an operation which will temporarily blind him. Addison makes plans to rob his own store knowing that his sightlessness will provide him with a perfect alibi. Things go wrong when someone kills the scheming Addison and steals the already pinched jewels. James Kincannon enlists Perry's aid when he's charged with the crime.

Carleton Gage, a major financial supporter of an orphanage, wants to keep it open but lapses into a coma and later assumes room temperature. Gage's nephew, George, wants to close the orphanage and he is being secretly aided by Ernest Demming. Joane Proctor, Carleton's sister-in-law, wants to keep the orphanage open but her good intentions are complicated by the murder of Demming.

Columnist Elihu Laban is hit with a murder rap when his efforts to obtain secret papers backfire.

Attorney Sherman Hatfield is sought out by a blackmail-plagued industrialist.

Perry has to defend the dean of a prep school on charges of murdering a teacher who had been stealing, embezzling, and blackmailing.

Gwynn Elston's best friend, Nell Grimes, asks her to move in with her due to the fact that Nell's husband, Felton, is often out of town on business. Gwynn, who has a door-to-door sales job, is then astonished to see Felton's picture in someone else's house where he's known as Frank Gillette. Felton, who's really a nasty mother, tries to poison Gwynn, when she confronts him but she survives and runs to Perry for help. Then Felton is found shot to death and things go from awful to good grief for poor Gwynn--she gets arrested for the crime.

Abner Gordon threatens to press charges if his niece doesn't replace the money she lifted from his safe.