After spending all day curing Lydia of her measles, Beetlejuice gets Cabin Fever--and then is quarantined to the Roadhouse. How can Lydia help BJ get over Cabin Fever if they can't go outside? They'll think of something!

Lydia has to write a paper on Shakespeare for her English class, but can't understand his plays. So BJ takes her to the Neitherworld to meet Shakey's characters, who turn out to be rather disgruntled with their roles. When they kidnap Lydia and try to force her to rewrite their plays, BJ must rescue her; then it's up to the both of them to cure Shakespeare of his monumental writer's block.

Oh, horrors! Beetlejuice's perfect brother Donnyjuice comes to visit, leaving BJ feeling...a bit down and out. Down-And-Outback, actually. Donny and Lydia set out to cheer Beetlejuice up before he does something drastic.