The first part of this episode introduces Ai Kaga, a girl who always takes blame for everything, even though it is not her fault. Nozomu takes the class to a "guilt scramble" to explain that history has led to the "guilt complex" such as Kaga's becoming the Japanese mentality. After being overcome with guilt himself, Nozomu and Kaga travel the world to try to stop burdening others. The second part introduces another girl, Mayo Mitama. Her evil-looking eyes have led to her being misunderstood - that is, she actually is evil, but people try not to prejudge her and assume she is actually good. She commits several cruel acts that Nozomu bears witness to and is blamed for, being the only other nearby party. He becomes so concerned with not prejudging that he doesn't blame her when she hits Majiru over the head with an aluminum bat or when she drops a brick onto Nozomu's head.

Nozomu Itoshiki, a direct marketing businessman, is chased by a mysterious religious group called Hamasho. At one point, he is caught and his body is modified like a mole cricket. After his long adventure, he is discovered by Kafuka and he then becomes a high school teacher. Students in the class start calling him "Left-wing Guerrilla" (apparently in lieu of "Pink Supervisor"), making him want to die again. Right before he jumps off a cliff, Kafuka suggests he "mock marry" a girl of the Holy Nosebleed Empire. A card reveals that the entire segment is a gag based on a summary from the jacket of the manga's first volume. In the second segment, Nami Hitō, who has been missing classes, finally decides to attend her school as no one really seems to notice her absence. Unfortunately, she does not get much attention from her classmates as the high school is full of extraordinary characters. At the end of the episode, most of the major characters are introduced and Nami is labeled as the 'ordinary girl' in the school.

A special summary episode of the second season of Sayonara Zetsubou Sensei, focusing on the girls that were not introduced in the first Zetsubou Shoujo Senshuu: Otonashi Meru, Fujiyoshi Harumi, Kaga Ai and Mitama Mayo.