Kafuka Fuura is cheerily walking to school one April morning when she suddenly spots a man trying to hang himself in a fit of despair. Kafuka manages to use her weight to snap the rope, thus saving his life. Nozomu Itoshiki, the man, eventually cannot take anymore of the girl's ridiculous ramblings, and runs off to school to start homeroom at the beginning of a new school year. When Nozomu walks in the door, he finds Kafuka is one of his students.

Chie dispatches Nozomu to investigate rumors that the invariably injured Abiru Kobushi is suffering from domestic violence. He pursues Abiru's father while he shops, causing him a great deal of inconvenience, before discovering Abiru's obsession with pulling the tails of dangerous animals. The latter half of the episode concerns Meru Otonashi, who is silent and shy in person, but remarkably abusive via text-messaging, her only means of communication.

The first part of this episode introduces Ai Kaga, a girl who always takes blame for everything, even though it is not her fault. Nozomu takes the class to a "guilt scramble" to explain that history has led to the "guilt complex" such as Kaga's becoming the Japanese mentality. After being overcome with guilt himself, Nozomu and Kaga travel the world to try to stop burdening others. The second part introduces another girl, Mayo Mitama. Her evil-looking eyes have led to her being misunderstood - that is, she actually is evil, but people try not to prejudge her and assume she is actually good. She commits several cruel acts that Nozomu bears witness to and is blamed for, being the only other nearby party. He becomes so concerned with not prejudging that he doesn't blame her when she hits Majiru over the head with an aluminum bat or when she drops a brick onto Nozomu's head.