In the premiere episode, the Chief of Surgery ends up in a coma, and his fiancée and fellow surgeons fight to save his life.

A routine surgical procedure goes awry when Alex's patient, a soon-to-be-wed young woman, falls into a coma. While Alex struggles with a case that hits close to home, Joel treats a patient who does his own body modifications, and Charlie finds himself drawn to Alex's coma patient in the spirit world.

The doctors at Hope Zion Hospital are forced to deal with people from their past as Alex, Charlie and Joel take on the daunting task of operating on a malpractice lawyer known for suing every doctor in his path. Meanwhile, Zach is tested when the last person he wants to treat comes into his E.R. and a Season 1 patient returns with some difficult insight for Charlie and Alex.

Celebrated neurosurgeon Thor MacLeod gives Alex an offer; Charlie deals with a fatigued spirit; Joel ends up in a fight at the clinic.

Casualties of a bomb at a local charity run arrive at Hope Zion Hospital.

Alex discovers that she unknowingly helped the bomber at the expense of a friend.