Dr. Grace Devlin must save the life of an old friend injured in a pub-crawl accident, while tasked by Constantine with delivering the child of a pregnant call girl. Meanwhile, Franco has to track down a young woman whose whereabouts are crucial to his boss.

As Constantine attempts to reconnect with his estranged son Garrett, who is deep in debt to the ruthless Nogales Cartel, he enlists the help of his Chicago mob colleague, Al Trapani (Mike Starr). As payback for the favor, Constantine orders Grace to diagnose Trapani’s girlfriend, a patient with a shocking secret who is experiencing inexplicable pains.