As Dr. Quinn is trying to persuade the townspeople that smallpox vaccinations are necessary, the father of Brain, Colleen, and Matthew arrives.

Mike loses custody of Brian and Colleen when their father, Ethan Cooper, arrives with new bride Lillian and reclaims them in a messy courtroom battle. Also, Myra and Horace are almost driven out of their minds by new baby Samantha's incessant crying.

Brian and Colleen run away from Ethan and Lillian, and Colleen contracts potentially lethal pneumonia, which, upon the kids apprehension, Mike treats. Also, surprisingly, Hank's the only person who can quiet Samantha, Myra and Horace's eternally crying baby.