When Mike and Sully stop to check on old Mrs. Johnson, they discover her dead and a young boy, Zack, hidden in the closet. Mike takes the child in and confronts the townsfolk, who reluctantly admit to knowing the boy's mother was one of Hank's whores. When she died they sent Zack to Mrs. Johnson because he was ""simple."" Mike is frustrated in her attempts to find a medical diagnosis and cure for Zack's condition. Mike's further detective work reveals that Hank is Zack's father, and she helps Hank own up to his responsibility.

Meanwhile, Brian seems to be the only one to get the boy to exhibit his artistic abilities, and he is mistakenly given credit for a drawing that Zack has done. Later, when Zack's artistic talent is discovered, Hank agrees to send him to an art school in Denver. The show has a cute opening scene of Mike and Sully with him criticizing her driving.

Halloween is trick-or-treat for the residents of Colorado Springs when Sully's dead wife, Abigail, haunts Dr. Mike, after Sully suggests fixing up the homestead for her. Eventually, Mike is able to lay Abigail's ghost to rest. Meanwhile, Brian becomes terrified after his investigations lead him to believe Dorothy is a witch. But, later she helps him deal with his sadness about the fading memory of his mother. Jake and Loren's prank on the town backfires when Jake pronounces a man dead and his ""corpse"" walks away -- Mike later diagnoses the man as a catalepsy sufferer.

Mike is called away to Soda Springs to help with an outbreak of influenza and Sully promises to stay with the children. Sully plays ""Mr. Mom"" but the kids grow restless. While out exploring caves with Brian, Sully is shot trying to intervene between the Indians and the cavalry. When the smoke clears, Brian can't locate Sully and goes to town for help. The Reverend helps the kids hide Sully, who now has a bounty on his head. They take Sully to the cave for safety. Colleen enlists the Reverend's help to bring supplies from the clinic, but he is spotted by Hank and Jake, who are out for the bounty. They knock Hank out and tie him up, but when Colleen is forced to remove the bullet, she must employ Jake's assistance to save Sully's life. When finally they ride back into town, the Cavalry tries to arrest Sully for blowing up the railroad, but the townsfolk provide Sully with an alibi preventing his arrest.

Catherine, a beautiful blond woman captured by and raised with renegade Indians, is brought to Colorado Springs by soldiers when her tribe, which includes her husband, is wiped out, leaving her the sole survivor. She initially earns the townsfolks' sympathy, then their contempt when she rejects their gestures of kindness, doesn't know the language, and falls down into an epileptic fit. Indeed, her Indian name was ""Shivering Deer"" thanks to her grand mal epileptic seizures.

Mike takes her in, but the only members of the family she trusts and feels comfortable with, especially with her faltering English, are Sully, then Brian. Brian, however, becomes decidedly less enamored of her when he accidentally glimpses Catherine kissing Sully. Later, when Brian confronts Sully, he doesn't understand Sully's distinction between ""being kissed"" and ""kissing someone,"" and troubled, tells Mike about it.

Meanwhile, Jake, in a conversation with Loren and Dorothy about what marauding Indians do to white

Eight orphans arrive on the train. The Reverend takes them in at the church and Mike nurses their ailments. When no one in the town wants to adopt the orphans, the Reverend extends a proposal of marriage to Mike so that they can raise the orphans together. Mike briefly considers the offer, and Sully confronts her about it, asking her if she loves him. She accuses him of not making any kind of committment to her, whereas the Reverend has, to which he replies, ""If marriage is all you want...."" leaving his meaning clear without being spoken that he's possibly willing to offer more. Considering this, Mike turns the Reverend down, much to the relief of Sully and the Cooper kids.

Eventually, the orphans board the train and leave town, but each orphan boards the train a more complete person as a result of their interaction with the townsfolk. Dr. Mike confronts the fact that she can't save the world and she and the Cooper kids emerge as a more united family.

Robert E buys a house in town. When the auctioneer, Jedediah Bancroft, sees that he's sold the house to a black man, he tries to renege, but Mike intercedes. Later, Mike is surprised to learn that Jake, Loren, Hank and Dorothy are displeased to have Robert E and Grace living in their midst.

That night, at the homestead, Matthew tells Mike he's been invited to join a new men's club -- the Ku Klux Klan, which he knows nothing about but is heading out the door to investigate. At the meeting, Jedediah, the leader of the group, promises only ""a big surprise"" for the following night, then adjourns the meeting. The next night, townsfolk don white gowns, recite the KKK oath, and ride out to harass and beat Robert E. After treating Robert E, Mike storms into the barbershop, where she confronts Jedediah, Jake, Loren and Hank about the events of the night before. Jedediah tries to make offers to get Robert E and Grace out of town, even threatening Mike with the mortgage on her clinic if Robert E

Only the town's love for the infinitely unlovable Hank can pull him from the brink of a deadly coma. Meanwhile, Colleen and Brian tangle when Grandma Quinn sends Brian but not Colleen a present.

Sully argues with Mike that they should move if the railroad comes. Meanwhile, Matthew feels left-out of Sully's new homestead plans.

Mike helps John, a man Brian finds in the woods, deal with outer and inner scars when she operates on his maimed face and helps him deal with his guilt about the train wreck that caused his disfigurement - as conductor of the train, he feels somehow responsible for the accidental crash. Meanwhile, the townsfolk are up in arms when they get wind that Mike's doing ""secret"" operations - and possibly creating Frankenstein's monster. John: Richard Moll

Mike discovers a lump in Dorothy's breast and performs a mastectomy on her. Meanwhile, Colleen must deal with the unwanted attention of a new boy at school who fixates on her impressive bust. Finally, Jake, dressed in drag for Ladies Night at Hank's saloon, gets kidnapped and held hostage by an amorous outlaw, but escapes.

Dorothy insists the decision to have surgery is hers, not Mike's; Colleen finds the harassment unbearable.

The town invites a traveling all-star baseball team for a fundraising event, but later suspects that they have been swindled. Otis James: Joel Anderson.