Dr. Mike prepares for the birth of her baby. Mike's family arrives for the impending birth of Mike and Sully's baby, bringing along a new young doctor (Brandon Douglas) to help deliver the baby. Meanwhile, Sully is hurt while trying to rescue Cloud Dancing and others from Sgt. O'Connor (Patrick Kilpatrick) and his patrol.

Wounded Sully must deliver Mike's baby. Dr. Cook is forced to perform a major operation. Katie Sully: Alexandria, McKenzie and Megan Calabrese.

Sully goes to Denver to negotiate the release of Cloud Dancing from the army. One of the conditions is that Sully is no longer Indian Agent and may not ever step foot on the reservation again. On the way home the train crashes, injuring most on board. Andrew learns a lesson in humility by watching Michaela in action.

Michaela has returned to work after being home with Katie. Between work, the baby and being so tired,Michaela is spread thin. Sully feels neglected. Sully helps Michaela through this difficult time. Colleen is accepted to college in Denver.

A malpractice suit prevents Dr. Mike from practicing medicine, leaving the reluctant Dr. Cook in charge.

Dr. Mike faces the prospect of leaving her practice and friends for Wyoming when Sully is offered a job surveying Yellowstone National Park.

Dr. Mike is arrested and put in jail for treating a fugitive Indian; Jake and Preston run against each other for mayor of Colorado Springs.

Dr. Mike, Sully and Matthew team up with a legendary marshal in order to nab the thieves who wounded Matthew during a bank robbery.

A severe storm bears down on Colorado Springs, disrupting the arrival of Preston Lodge II and Dr. Mike's attempts to prepare a Thanksgiving dinner.

When three people die after coming in contact with something in the clinic, and one is deathly sick, Dr. Mike, Sully, Colleen, and Andrew but their heads together to find out what it was. They figure out that it was something in the clinic and now it is everywhere. In her case, on the instruments, the sheet. The only solution is to burn everything. When that is done, some are genorous enough to give Dr. Mike some of there things, but they are scared to come in. When Sully must get stitches, and lives after being treated by Dr. Mike, she begins the road to being reaccepted by Colorado Springs.

As Christmas approaches, Brian questions his faith when he learns that Dr. Mike cannot save the sight of the Reverend.

When Colleen, who is working on a college paper, asks Dr. Mike to recall her most memorable case, Dr. Mike looks back on the five turbulent years she's lived and loved in Colorado Springs. As they sit with Andrew, who is mysteriously ill at the clinic, Dr. Mike reminisces about her tumultuous career -- its successes and its failures -- and realizes how many divergent cases she has seen and treated.

When Andrew's condition takes a turn for the worse, Dr. Mike warns Colleen about the fine line between emotional involvement and professional detachment, an issue with which she has long struggled in the frontier town that's now her home.

Sully, depite being wounded by two bank robbers, works to free his wife, Brian and Katie when they are taken hostage by the desperate men.

Brian takes a liking to visiting writer Walt Whitman, even when the townspeople shun Whitman over rumors of his alternative lifestyle.

Sgt. O'Connor was found dead in the river. Sully is nowhere to be found. Michaela believes that he survived and goes looking for him. Daniel comes to offer his help. Dorothy and Cloud Dancing share their first kiss.

Cloud Dancing is badly beaten by soldiers for returning late to the reservation. Michaela treats him. When Sully learns of the attack, he is outraged. Tired of being treated cruelly, the tribes plan a rebellion. They enlist Sully's help.

After Marjorie joins the Women's movement she blows into town stirring everyone up and has a fling with Loren.

Sully arranges an escape for Cloud Dancing, leading him and the Indian to become wanted men.

Everyone is doting on Katie and Brian feels slighted. Brian receives a letter and picture from his real father, which leaves him feeling like he doesn't belong anywhere. Brian starts behaving badly. He gets Anthony to skip school with him and they hop a train. Sully punishes Brian. When Brian questions Sully's actions, Sully says that he is doing it because he is his Pa.

Sully lies to everyone about what he is doing, but the truth comes out. Cloud Dancing flees to the Tongue River Valley. Sgt McKay (David Beecroft)sees Sully at the scene. After Sgt O'Connor (Patrick Kilpatrick) finds out what happens, he goes after Sully. They get into a fight and they both go over a cliff

Sully is found alive, but badly hurt. As Michaela nurses him back to health, she keeps him hidden from the army. Sully sneaks into the homestead one night to spend time with his wife.

Sully is wanted for treason and murder. In order to keep him safe, Michaela pretends that Sully is dead and has a memorial service for him. Hank and Jake find out Sully is alive. Cloud Dancing and Sully meet with Black Moon.

Michaela finds out that she is pregnant, but suffers a miscarriage. Without Sully there to comfort her, she has to turn to her friends.

Anthony's (Brandon Hammond) health deteriorates rapidly. Grace does not want to face the inevitable. Michaela struggles to tell Sully about the baby. Anthony loses his battle.

Marjorie brings a group of Temperance Women (opposed to alcohol consumption) to C.S. Jake goes on a dangerous drinking binge, when he thinks Hank and Teresa are seeing each other. Grace begins to drink heavily to numb her grief. Robert E. moves out.

A diptheria epidemic sweeps through C.S. Michaela performs a procedure that is not a proven cure. Becky (Haylie Johnson) dies.

Mrs. Quinn wants to take to the children to Boston with her. She also disapproves of Loren and Marjorie's relationship. Marjorie contracts the illness. The family sneaks Sully home for Thanksgiving.

Dorothy discovers the deed to the property that Grace's cafe is on. Hank accidently breaks Horace's nose and won't pay for the damage. There is a sudden rash of lawsuits and Michaela acts as Judge.

Michaela is shot at the clinic by a man that has a grievance with doctors. The physical wounds heal, but the emotional ones linger.

A male acquaintance of Colleen's from Denver, starts to call on her. When the man pushes himself on Colleen, Andrew protects her honor and admits his love for her.

Loneliness pervades C.S. as the Sweetheart's Dance approaches. Loren sells his store to Preston and plans to move to San Francisco. Jake proposes to Teresa.

Chinese immigrants set up camp. Dr. Quinn discovers a young woman (Yumi Iwami) posing as a man in order to practice medicine, which is forbidden in her culture. Her Grandfather (Robert Ito) is stunned, but supportive.

Hank captures Cloud Dancing and gets the army to send him to a reservation far away. Jake and Teresa marry, despite her aunt's (Carmen Zapata) disapproval.

Robert E releases anger over his separation from Grace through his furious fists in the boxing ring, where he takes on an ailing champ (Richard Roundtree) who's on tour.

Dr. Mike's elation at Colleen's acceptance to medical school quickly turns to disappointment when Colleen chooses to marry Andrew instead. A bitter family argument erupts when Dr. Mike tells Colleen that she is less than overjoyed at her announcement and feels that the couple is rushing into marriage and should wait until Colleen completes medical school. Meanwhile, Robert E and Grace have wonderful news to share; the stock market crash hits Preston and the townsfolk hard; and Dorothy and Cloud Dancing reach a new level in their relationship. As part of the Network's 50th Anniversary celebration, classic footage of James Arness as legendary Marshal Matt Dillon of ""Gunsmoke"" is digitally integrated into this episode. When Jake breaks the news to Hank that he's accepted Preston's offer to buy his share of the Golden Nugget that would make him partners with the despised Preston,