Amanda and Jo invest in Reed's business, and Jake is hired as chief mechanic. Jo displays a lack of trust toward Reed after he leaves a suitcase of personal possessions in her care. Michael becomes addicted to painkillers. Jane files a restraining order against him. She calls the police when Michael shows up at her apartment, but Sydney gives him refuge. After Michael talks Syd into getting him more pills, she finds him passed out on his bathroom floor. Alison refuses to move to New York with Billy, and suggests they try a long-distance relationship. Jeffrey fears that his relationship with Matt could jeopardize his career.

Amanda is furious when Jake skips work to hold a bedside vigil for Jo. Jo is not seriously injured, and learns that her baby was unharmed. Billy warns Alison to keep quiet about Amanda's rendezvous with Chas. Jake tracks down Hank at a pool hall and beats him up. He shows up late for dinner with Amanda, sporting a black eye, and storms out when she lambastes him for defending Jo. Michael throws Billy a bachelor party at a strip club, unaware that Sydney is the entertainment. When she sees Michael, she runs out of the club and is fired. A drunken Billy accidentally tells Jake about Amanda and Chas. Jake breaks up with Amanda, who fires Chas and vows to destroy Alison. Jake admits his feelings for Jo, and she agrees to take him back. Kimberly alters the chart of one of Michael's patients, prompting him to unwittingly commit an error that nearly kills the man. He is stripped of the chief resident position. Kimberly bullies Jane into turning over the $5000 in profits she had kept from Mich