In a world where minds can be analysed for potential threats of crime and mental instability, Inspector Tsunemori Akane is sent to deal with her first case, along with fellow inspector Ginoza and a group of Enforcers, latent criminals hired by the police to work for them. Akane’s case deals with an insane man who has taken a woman hostage and raped her, holing himself up in a building inhabited by groups of the homeless.

While Kogami is recuperating from Akane’s Paralyzer shot, she begins to worry about whether she is suited to be an Inspector after the fallout from her first case. On her second day on the job, she begins to learn more about the Enforcers she works with.