In part one of the crossover with Law & Order: During a house fire, Firehouse 51 rescues the owner from the cellar clutching a suspicious box, leading Lt. Severide to bring in Sergeant Voight and Detective Lindsey for further investigation.

The crossover continues on Law & Order: Special Victims Unit S16E07 Chicago Crossover (II) and Chicago P.D. S02E07 They'll Have to Go Through Me (III).