Lt. Casey is unable to rescue a woman who becomes trapped inside her burning greystone, prompting him and Lt. Severide to butt heads over the husband's role in the tragedy. Herrmann is on a mission to catch a mystery tagger that keeps targeting their firehouse and Boden gets a surprise visitor. Meanwhile, Dawson and Brett respond to a 16-year-old boy who was injured during a romantic homecoming proposal.

While responding to a call in the field, Dawson accidentally hits a pedestrian who stepped in front of the ambulance, and is left to deal with the repercussions. Lt. Casey and Lt. Severide disagree and continue to investigate an arson case while Chief Boden is left to decide whether to attend an important function in New York. Elsewhere, in hopes of preparing him for a possible promotion, Lt. Casey puts Herrmann at the helm for a shift so he can discover firsthand what his superiors deal with.

Truck and squad are called to aid in a massive all-city response when an old, ill-equipped factory-turned live/work space quickly turns into a firestorm, trapping countless unsuspecting victims. The dire situation quickly turns personal when it is discovered that one of Chicago PD's own has a family member at the scene.

The crossover continues on Chicago P.D. S04E016 Emotional Proximity (II) and Chicago Justice S01E01 Fake (III).

When a turf war escalates, members of truck and squad find themselves caught in the middle as unsuspecting hostages when a group of armed gang members take cover and assume control over Firehouse 51.

After learning the school fire wasn't an accident, Chief Boden turns up the pressure on Severide and Casey to investigate the cause of the fire that trapped his wife. Fueled by a competitive bet against Firehouse 87, Mouch pushes all of the wrong buttons in his need to win the competitive challenge known as the firefighter muster. Meanwhile, as Kidd settles into her new living arrangement, her unresolved feelings prompt her to question the intentions of newcomer Hope.

Brett and Dawson go undercover at Voight's request, and Boden and Severide provide critical intel for P.D. as they race to stop a serial bomber.

The crossover starts on Chicago P.D. S05E016 Profiles (I).

Severide and Boden search to uncover whether arson was the cause of a fire at a hair salon. Mouch, Herrmann, Otis and Kidd make a startling discovery in tracking down the missing piercing nozzle from Engine 27.

A serial arsonist cold case is reopened when Lt. Severide finds a connection to a recent salon fire. Firehouse 51 celebrates a retirement party.

Severide and Kidd continue to investigate Benny’s old arson case, unexpected news leads Brett to ponder a big decision and all hell breaks loose.