Mindy isn't getting respect from Danny and Jeremy, so she goes off to experience life as her own boss. Meanwhile, the group fights back when they discover that holistic midwives are stealing patients from Shulman & Associates.

When Mindy's brother visits from college, he tells Mindy that he wants to drop out and start a rap career, immediately causing Mindy to panic. Meanwhile, Danny and Jeremy lift the spirits of their elderly landlord with the hopes that she will reduce their office rent.

Mindy wants a one-night stand with Brendan, the midwife who once stole her patients, but things go wrong when Brendan's brother, Duncan, and Morgan show up. Meanwhile, Eye Patch and Danny go out on a date.

Mindy's friends and co-workers unintentionally throw her the worst birthday party ever. And, after storming out, Mindy stumbles upon a new group of friends with whom to celebrate. But when she ends up in a fight with her new pals, she receives help from someone in her recent past. Meanwhile, Danny and Jeremy compete for the affection of Mindy's friend.

When Mindy decides to have a night out by herself in the city, she hits it off with a stunningly handsome man who turns out to be a prostitute.