After using a repellent to temporarily prevent the Powerpuff Girls from moving, Mojo Jojo uses a teleportation device to teleport himself into Jump City, in the Titans' tower, then the girls follow him into the same place where he appeared, only to run into Robin, Starfire, and Raven. Then, after the girls compete with three of the Titans to see who's better, and Mojo Jojo traps Cyborg and Beast Boy in his new lair, the girls defeat him, with "help" from Robin, Starfire, and Raven.

The Titans are in charge of the 100th anniversary party for Warner Bros on the studio lot, and everything is going well until the magical WB Shield is broken into pieces.