Emily suffers a major embarrassment in front of her colleagues at the hands of a drug-impaired patient. In the aftermath, Emily decides to follow Dr. Bandari's advice and tries to toughen up. Emily and Will find that a teenage patient needs a partial liver transplant, but they uncover some surprising information when neither of the teen's parents is a match. Meanwhile, Cassandra starts treating Emily better in an effort to learn more about Will, and Tyra sets Emily up on a date with her ex, a fact which she doesn't reveal to Emily.

A beloved flower-delivery man collapses, but he is reluctant to get treatment. Meanwhile, Emily and Will are assigned to help a sick prisoner, but they find it difficult to remain professional and not let his crimes cloud their judgment.