Emily talks about safe sex to some girls at a local high school; and she tries to forget about her feelings for Will.

Emily treats an infant and a deeply religious man whose faith is shaken following surgery. Meanwhile, Will breaks protocol with a risky diagnosis; and Tyra considers telling her father that she is a lesbian.

When a female car accident victim is brought into the ER with a spike through her torso, everyone immediately blames her boyfriend for causing the accident. She makes it through surgery, but the doctors find that she may be paralysed. Later, they discover that the boyfriend has lupus, which could be to blame for the accident. The case brings up painful memories for Will. Emily deals with a model with jaw cancer who refuses to undergo surgery. Emily and Cassandra compete for Will's attention as they all prepare for the in-service exam.

When the hospital is inundated with bus crash victims during a winter storm, Emily is assigned to run triage in the E.R. During the chaos, Emily is forced to do an emergency skull procedure on a heroic Marine who suddenly collapses. Tyra bristles at her father’s lack of respect for her as a doctor, but they later experiences a breakthrough when they perform an emergency c-section together. Meanwhile, Will and Emily secretly work to help an unexpected patient leaving Cassandra to question Will’s true feelings for Emily. Micah finally makes a bold decision in his personal life.