After a year long absence, Dr. A.J. Aquino returns to Denver Memorial, but before he can rejoin the staff, the Chief insists that he make peace with Dr. Bandari. Emily is tasked with treating a patient who claims to be a psychic, and is convinced that her tarot cards predict her own impending death. Elsewhere, Cassandra and Dr. Bandari treat a patient who needs a lung transplant, but Micah’s discovery of a new medical issue leaves the patient with a tough decision. Meanwhile, Emily decides to test her theory that Will was jealous of her recent date, so Tyra offers to teach Emily how to flirt.

When the hospital is inundated with bus crash victims during a winter storm, Emily is assigned to run triage in the E.R. During the chaos, Emily is forced to do an emergency skull procedure on a heroic Marine who suddenly collapses. Tyra bristles at her father’s lack of respect for her as a doctor, but they later experiences a breakthrough when they perform an emergency c-section together. Meanwhile, Will and Emily secretly work to help an unexpected patient leaving Cassandra to question Will’s true feelings for Emily. Micah finally makes a bold decision in his personal life.

Season Finale: Emily's decision about starting a relationship with Micah becomes even more complicated when Will hears about it and begins to feel jealous. Emily and Tyra treat an unruly woman, but after learning of her home hoarding situation, Emily wonders if the woman's personality changes may be caused by her many cats. Now that Cassandra and Will have broken up, Cassandra's strictly professional behavior distracts Will and causes him to misdiagnose their patient. Meanwhile, Micah's sister comes to town after finding out the truth about their mother.