Tony Stark is backing a charity racing event in order to burnish the image of Stark Industries. Meanwhile, Kawashima, a race car driver who's suffered career-threatening injuries, is won over by A.I.M./Zodiac who promise him they will heal his injuries if he takes out Tony Stark.

Dr. Tanaka informs Tony that a mysterious epidemic has broken out near the Arc Station. The rampant and deadly disease appears unstoppable, and Tony initiates his own investigation into the cause. Meanwhile, the Self Defense Forces reconnaissance satellites are acting up, and Nagato Sakurai visits Iron Man to ask for his help. Stark and Sakurai join forces, when they discover the Zodiac Mech Aquarius may be behind both.

Tony and Dr.Tanaka are wake up on an isolated island with no idea how they got there and no hope of getting off the island. Missing his life-saving arc reactor and without his Iron Man armor, how will Tony and Chika be able to escape? And, who put them there in the first place?

Held responsible for the event at the Arc Station, Tony Stark is arrested by the Japanese government. But while being transported, explosions rock the Diet parliament building, and suspicions are raised that Stark is behind it. Will Tony Stark be able to clear his name, and take out the real threat behind the Diet bombing?