It's Breast Cancer Awareness Weekend at the Rittenhouse Hospital Women's Clinic, where Lu (Rosa Blasi), Lana (Jenifer Lewis) and Peter (Josh Coxx) are hosting a dance-a-thon and a free mammogram clinic. When one woman's mammogram reveals a lump, she must choose between losing both her breasts and losing her job. After Dana (Janine Turner) delivers the unexpected results of her breast cancer clinical trial, she learns the very disease that's defined her career has now hit too close to home.

When a 12-year-old girl is diagnosed with oral gonorrhea, she tells Lu (Rosa Blasi) that she got it from her teacher. Lana (Jenifer Lewis) takes on a new role at Rittenhouse: that of patient. Two of Dana's patients deliver babies — and both newborns have the same father.

The second season begins with Dana and Lu at odds over the fate of a dead college student's fertilized eggs. The day is further complicated by the arrival of Peter's mother, who clings to the idea that her heterosexual son is gay. Elsewhere, a dying patient and her husband wait impatiently for a donor heart and Nick's appointment to the ER staff is in doubt.

A pregnant and very ill pro-life politician has her principles put to the ultimate test when the only treatment that will save her life will result in losing her baby. Meanwhile, a patient of Lu's who is trying to pass herself off as a much younger woman is hampered by the inconvenient arrival of menopause.

Lu copes with the trauma of being raped by devoting her thoughts to a patient who accidentally overdosed on over-the-counter cough medicine. Dana, meanwhile, grudgingly turns to Dr. Kilner for advice about a pregnant woman with colon cancer.

When Dana's attorneys make Peter's being a sperm donor difficult, Dana considers getting pregnant the old-fashioned way. Lu suspects that a baby's mother is the one responsible for the child's mysterious sickness.

Lu faces the doctor that raped her when he needs surgery that can save his life. Peter goes out with a woman who has terminal diabetes.

As a heat wave hits Philadelphia, Andy & the staff will need to get used to its disaster plan to cope with heat wave. Claire a patient of Dr. Campbell is told she will develop Alzheimer's disease within 10 years, she also wants to have a baby.

Andy & tells her kids about Dr. Morton, her kids question why she can't make time for kids. Clare worries that her kids might have the gene PGD (the gene that leads to finding Alzheimer's early.)

A young girl with Down's Syndrome tells Lu she shot a girl to get in a gang. The mother later tells Lu that she had her 16 year old (with Downs Syndrome) confess to the crime to protect her sister who actually committed the crime.

Ben Sanderson wants to cut screening tests for newborns. A patient of Lu's thinks a patient of Andy's is a fugitive but doesn't believe it. Everyone worries if they will have jobs if Octavian Systems takes over Rittenhouse. Andy is asked to stay on a Rittenhouse, and fights for Dr. Jackson's job.

Nick is transferred to Manhatten General. Ben's HIV test has a positive result. Also, Ben hires his ex-wife to make up for the damage he caused to her career. Andy learns that her daughter Jesse's friend is addicted to cough syrup. Kayla Thorton, a new intern, is pushed into the hustle and bustle of the ER. She gets into trouble when she asks a girl if she is sexually active in front of her mother and things go terribly wrong.

Jesse gives her friend CPR to save her life after she loses consciousness due to consuming too much syrup. Andy feels responsible for the incident because Jesse's friend was in her care.

Lana bets her pink feather pen that she'll sign up more people than a friend will for the Rittenhouse Breast Cancer Walk. She faces some difficulties, however, and goes to extreme measures to get people to sign up. Lu tells a teenaged patient that she is pregnant and she in turn tells Lu that Lu's son Marc is the father. In a shocking ending, the girl reveals a horrifying secret. Andy, meanwhile, takes action when Lizzy's friends receive ""fat letters"" and instead makes the school food healthier when Lizzy starts to severely diet.

Andy must face the questions of people opposed to her becoming Surgeon General while she struggles to get Senate confirmation. Lu's unique way of practicing medicine and their relationship challenge her chances. Kayla and Peter prepare for the next step in their relationship but struggle to find privacy. Lu reads something in a newspaper about Jonas that could change their relationship forever.