Dana treats an HIV positive patient of Lu's when Lu is out of the clinic and learns that his mother took him off the HIV medication with Lu's permission. She is furious and reports the mother. Although the boy suffers terrible side effects from the medication, Dr. Bob Jackson insists that he be put back on it. Dana falls for her handsome intern.

An estranged sister must work up the courage to ask her Olympic gymnast sibling to donate her liver to save her life. Andy and Kayla help a clinically depressed and struggling resident get back on track after a suicide attempt. Lu tries to convince Jonas not to build a large discount multi-purpose store in her neighborhood as it would close down many of the mom and pop stores that had been there for years.